Human CGRPR and RAMP1 Heterodimer Protein, hFc Tag and mFc Tag

Description :Recombinant human CGRPR protein with C-terminal human Fc tag and human RAMP1 protein with C-terminal mouse Fc tagBackground : The CGRP receptor (CGRPR) is a member of family B G protein coupled receptors (GPCRs), is expressed throughout the trigeminal system, including neurons and endothelial cells. They usually function with accessory proteins such as receptor activity modifying proteins (RAMPs) and Na/H exchange regulatory factors (NHERFs) . CGRPR is a heterodimer complex of the calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein 1 (RAMP1) . Therapeutics for migraine treatment are mostly targeting CRLR-RAMP1 protein-protein interaction surfaces, thereby blocking CGRP activity.Molecular Characterization: mass of 39.9 and 36.7 kDa after removal of the signal peptide. The apparent molecular mass of CGRPR-hFc and RAMP1-mFc is approximately 35-70 kDa due to glycosylation.Tag :C-Human Fc tag and C-mouse Fc tag