Human ITGAV and ITGB6 Heterodimer Protein, His Tag and hFc Tag

Description :Recombinant human ITGAV protein with C-terminal6Ã-His tag and human ITGB6 protein with C-terminal human Fc tagBackground : Integrin alpha V beta 6 is a heterodimer of beta-6 associating with alpha-V. Integrin alpha-V beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. Also, Integrin alpha-V beta-6 acts as a receptor for coxsackievirus A9 and coxsackievirus B1 as well as herpes simplex virus-1/HHV-1. Furthermore, it binds the TGF-beta latencyÃ¢â‚¬â€ ̃associated peptide (LAP) and activates TGF-beta 1 or TGF-beta 3 from large latent complexes. This activation requires interaction with LTBP-1 and fibronectin, and is enhanced by PAR-1.Molecular Characterization: mass of 107.1 and 100.4 kDa after removal of the signal peptide. The apparent molecular mass of ITGAV-His abd ITGB6-hFc is approximately 130-250 kDa due to glycosylation.Tag :C-6Ãƒâ€”His tag and C-Human Fc tag

Product Specifications

Product Name Alternative

CD51; MSK8; VNRA; VTNR and AI1H

UniProt

P06756 and P18564

Host

HEK293

Target Antigen

ITGAV and ITGB6

Purification

The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.

Components

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization.

Storage Conditions

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing) . Lyophilized proteins are shipped at ambient temperature.