Human PDGFRA Protein, His Tag

Description :Recombinant human PDGFRA Protein with C-terminal6Ã-His tagBackground : This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. Molecular Characterization: mass of 57.4 kDa after removal of the signal peptide. The apparent molecular mass of PDGFRA-His is approximately 100-130 kDa due to glycosylation.Tag :C-6Ãƒâ€”His tag

Product Specifications

Product Name Alternative

CD140A; PDGFR2; PDGFR-2

UniProt

P16234

Host

HEK293

Target Antigen

PDGFRA

Purification

The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.

Components

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization.

Storage Conditions

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing) . Lyophilized proteins are shipped at ambient temperature.