Human LEPR Protein, His Tag

Description :Recombinant human LEPR Protein with C-terminal6Ã-His tagBackground : The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021) .Molecular Characterization: mass of 94.3 kDa after removal of the signal peptide. The apparent molecular mass of LEPR-His is approximately 130-250 kDa due to glycosylation.Tag :C-6Ãƒâ€”His Tag

Product Specifications

Product Name Alternative

OBR; OB-R; CD295; LEP-R; LEPRD

UniProt

P48357

Host

HEK293

Target Antigen

LEPR

Purification

The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.

Components

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization.

Storage Conditions

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing) . Lyophilized proteins are shipped at ambient temperature.