Human EGFRVIII Protein, His Tag

Description :Recombinant Human EGFRVIII Protein with C-terminal6Ã-His tagBackground : The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer.Molecular Characterization: mass of 39.5 kDa after removal of the signal peptide. The apparent molecular mass of EGFRVIII-His is approximately 55-100 kDa due to glycosylation.Tag :C-6Ãƒâ€”His Tag

Product Specifications

Product Name Alternative

EGFR; ERBB; ERBB1; HER1; PIG61; mENA

UniProt

P00533

Host

HEK293

Target Antigen

EGFRVIII

Purification

The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.

Components

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization.

Storage Conditions

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing) . Lyophilized proteins are shipped at ambient temperature.