Human LOX-1 Protein, hFc Tag

Description :Recombinant Human LOX-1 Protein with N-terminal human Fc tagBackground: This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]Description: Recombinant Human LOX-1 Protein with N-terminal human Fc tagMolecular Characterization: hFc (Glu99-Ala330) LOX-1 (Met58-Gln273) Molecular Weight :The protein has a predicted molecular mass of 50.9 kDa after removal of the signal peptide. The apparent molecular mass of hFc-LOX-1 is approximately 55-70 kDa due to glycosylation.Tag :N-Human Fc Tag

Product Specifications

Product Name Alternative

CLEC8A; LOX1; LOXIN; SCARE1; SLOX1; OLR1

UniProt

P78380

Host

HEK293

Target Antigen

LOX-1

Purification

The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.

Components

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization.

Storage Conditions

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing) . Lyophilized proteins are shipped at ambient temperature.