Human IL21R Protein, mFc Tag

Description :Recombinant Human IL21R with C-terminal mouse Fc tag Background : The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21) . It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. Molecular Characterization: mass of 50.7 kDa after removal of the signal peptide.The apparent molecular mass of IL21R-mFc is approximately 55-70 kDa due to glycosylation. Tag :C-Mouse Fc Tag