Human IL4RA Protein, mFc Tag

Description :Recombinant Human IL4RA with C-terminal mouse Fc tag Background : This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. Molecular Characterization: mass of 49.8 kDa after removal of the signal peptide.The apparent molecular mass of IL4RA-mFc is approximately 70-100 kDa due to glycosylation. Tag :C-Mouse Fc Tag