Recombinant Human GPNMB Protein, His Tag

Molecular Characterization: GPNMB (Lys23-Met496) 6Ã-His tagMolecular weight: The protein has a predicted molecular mass of 53.9 kDa after removal of the signal peptide. The apparent molecular mass of GPNMB-His is approximately 70-130 kDa due to glycosylation.Description: Recombinant Human GPNMB Protein with C-terminal6Ã-His tagThe protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene.