Recombinant Human LY6H Protein, hFc Tag

Molecular Characterization: LY6H (Leu26-Gly115) hFc (Glu99-Ala330) Molecular weight: The protein has a predicted molecular mass of 36.0 kDa after removal of the signal peptide. The apparent molecular mass of LY6H-hFc is approximately 35-55 kDa due to glycosylation.Description: Recombinant Human LY6H Protein with C-terminal human Fc tagBelieved to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3: beta-4-containing nAChRs maximum response. May play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface. Seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons.[UniProtKB/Swiss-Prot Function]