Recombinant Human RHOC (1-189) Protein, hFc Tag

Molecular Characterization: RHOC (Met1-Gly189) hFc (Glu99-Ala330) Molecular weight: The protein has a predicted molecular mass of 47.7 kDa after removal of the signal peptide. The apparent molecular mass of RHOC (1-189) -hFc is approximately 35-55 kDa due to glycosylation.Description: Recombinant Human RHOC (1-189) Protein with C-terminal human Fc tagThis gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.