Recombinant Human ACVRL1 Protein, hFc Tag

Molecular Characterization: ACVRL1 (Asp22-Gln118) hFc (Glu99-Ala330) Molecular weight: The protein has a predicted molecular mass of 36.8 kDa after removal of the signal peptide. The apparent molecular mass of ACVRL1-hFc is approximately 35-70 kDa due to glycosylation.Description: Recombinant Human ACVRL1 Protein with C-terminal human Fc tagThis gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.

Product Specifications

Product Name Alternative

ACVRLK1; ALK-1; ALK1; HHT; HHT2; ORW2; SKR3; TSR-I

UniProt

P37023

Host

HEK293

Target Antigen

ACVRL1

Components

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization.

Storage Conditions

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing) . Lyophilized proteins are shipped at ambient temperature.