Recombinant Human ACVR1C Protein, hFc Tag

Molecular Characterization: ACVR1C (Leu22-Glu113) hFc (Glu99-Ala330) Molecular weight: The protein has a predicted molecular mass of 36.0 kDa after removal of the signal peptide. The apparent molecular mass of ACVR1C-hFc is approximately 35-70 kDa due to glycosylation.Description: Recombinant Human ACVR1C Protein with C-terminal human Fc tagACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]) .[supplied by OMIM, Mar 2008]

Product Specifications

Product Name Alternative

ACVRLK7; ALK7

UniProt

Q8NER5

Host

HEK293

Target Antigen

ACVR1C

Components

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization.

Storage Conditions

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing) . Lyophilized proteins are shipped at ambient temperature.