Recombinant Human IL23A & IL12B Heterodimer Protein, hFc Tag & His Tag

Molecular Characterization: IL23A (Arg20-Pro189) hFc (Glu99-Ala330) and IL12B (Ile23-Ser328) 6Ã-His tagMolecular weight: The protein has a predicted molecular mass of 44.8 and 35.5 kDa after removal of the signal peptide. The apparent molecular mass of IL23A-hFc and IL12B-His is approximately 35-55 kDa due to glycosylation.Description: Recombinant human IL23A protein with C-terminal human Fc tag and human IL12B protein with C-terminal6Ã-His tagInterleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.