Recombinant Human SIGLEC5 Protein, His Tag

Molecular Characterization: SIGLEC5 (Glu17-Thr434) 6Ã-His tagMolecular weight: The protein has a predicted molecular mass of 47.2 kDa after removal of the signal peptide. The apparent molecular mass of SIGLEC5-His is approximately 55-100 kDa due to glycosylation.Description: Recombinant Human SIGLEC5 Protein with C-terminal6Ã-His tagThis gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig) -like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion.

Product Specifications

Product Name Alternative

CD33L2; CD170; OB-BP2; OBBP2; SIGLEC-5

UniProt

O15389

Host

HEK293

Target Antigen

SIGLEC5

Components

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization.

Storage Conditions

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing) . Lyophilized proteins are shipped at ambient temperature.