Recombinant Human BMPR1A Protein, hFc Tag

Molecular Characterization: BMPR1A (Gln24-Arg152) hFc (Glu99-Ala330) Molecular weight: The protein has a predicted molecular mass of 40.3 kDa after removal of the signal peptide. The apparent molecular mass of BMPR1A-hFc is approximately 35-70 kDa due to glycosylation.Description: Recombinant Human BMPR1A Protein with C-terminal human Fc tagThe bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.