Recombinant Human LDLR Protein, His Tag

Molecular Characterization: LDLR (Ala22-Arg788) 6Ã-His tagMolecular weight: The protein has a predicted molecular mass of 85.6 kDa after removal of the signal peptide. The apparent molecular mass of LDLR-His is approximately 100-130 kDa due to glycosylation.Description: Recombinant Human LDLR Protein with C-terminal6Ã-His tagThe low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.

Product Specifications

Product Name Alternative

FH; FHC; FHCL1; LDLCQ2

UniProt

P01130

Host

HEK293

Target Antigen

LDLR

Components

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization.

Storage Conditions

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing) . Lyophilized proteins are shipped at ambient temperature.