Recombinant Human TIMP1 Protein, hFc Tag

Molecular Characterization: TIMP1 (Cys24-Ala207) hFc (Glu99-Ala330) Molecular weight: The protein has a predicted molecular mass of 46.8 kDa after removal of the signal peptide. The apparent molecular mass of TIMP1-hFc is approximately 55-70 kDa due to glycosylation.Description: Recombinant Human TIMP1 Protein with C-terminal human Fc tagThis gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.