Recombinant Human IL23A Protein, hFc Tag

Molecular Characterization: IL23A (Arg20-Pro189) hFc (Glu99-Ala330) Molecular weight: The protein has a predicted molecular mass of 44.8 kDa after removal of the signal peptide. The apparent molecular mass of IL23A-hFc is approximately 35-55 kDa due to glycosylation.Description: Recombinant Human IL23A Protein with C-terminal human Fc tagThis gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23) . IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B) . The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG) . In contrast to IL12, which acts mainly on naive CD4 () T cells, IL23 preferentially acts on memory CD4 () T cells.

Product Specifications

Product Name Alternative

IL-23; IL-23A; IL23P19; P19; SGRF

UniProt

Q9NPF7

Host

HEK293

Target Antigen

IL23A

Components

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization.

Storage Conditions

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing) . Lyophilized proteins are shipped at ambient temperature.