Recombinant Human CNTF Protein

Molecular weight: 22.93 KDaDescription: Recombinant Human Ciliary Neurotrophic Factor is produced by our E.coli and the target gene encoding Ala2-Met200 is expressed.Ciliary Neurotrophic Factor (CNTF) is a potent survival factor for neurons and oligodendrocytes. CNTF has also been shown to prevent the degeneration of motor axons after axotomy. CNTF is highly conserved across species and exhibits cross-species activities. Human and rat CNTF share approximately 83% homology in their protein sequence. CNTF is structurally related to IL6, IL11, LIF and OSM. All of these four helix bundle cytokines share gp130 as a signal transducing subunit in their receptor complexes. CNTF, like FGF acidic, FGF basic, and PD-ECGF (platelet-derived endothelial cell growth factor), does not possess a signal sequence that would allow secretion of the factor by classical secretion pathways. The mechanism underlying the release of CNTF is unknown.

Product Specifications

Product Name Alternative

Ciliary Neurotrophic Factor; CNTF

UniProt

P26441

Host

E.coli

Target Antigen

CNTF

Components

Lyophilized from a 0.2 ?m filtered solution of 20mM Tris-HCl, 100mM NaCl, pH 8.0.

Storage Conditions

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing) . Lyophilized proteins are shipped at ambient temperature.