Recombinant Human PDGF-BB Protein

Molecular weight: 12.42 KDaDescription: Recombinant Human Platelet-Derived Growth Factor BB is produced by our E.coli and the target gene encoding Ser82-Thr190 is expressed.Platelet-Derived Growth Factor Subunit B (PDGFB) belongs to the PDGF/VEGF growth factor family. Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma.Binding of PDGFB to its receptor elicits a variety of cellular responses. In addition, PDGFB is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound.

Product Specifications

Product Name Alternative

PDGFBB; PDGF-BB

UniProt

P01127

Host

E.coli

Target Antigen

PDGF-BB

Components

Lyophilized from a 0.2 ?m filtered solution of 20mM NaAc-HAc, pH 4.5.

Storage Conditions

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing) . Lyophilized proteins are shipped at ambient temperature.