Recombinant Human DLK1 Protein, His Tag

Molecular Characterization: DLK1 (Ala24-Gln303) 6Ã-His tagMolecular weight: The protein has a predicted molecular mass of 30.6 kDa after removal of the signal peptide. The apparent molecular mass of DLK1-His is approximately 35-55 kDa due to glycosylation.Description: Recombinant human DLK1 protein with C-terminal6Ã-His tagThis gene encodes a transmembrane protein that contains multiple epidermal growth factor repeats that functions as a regulator of cell growth. The encoded protein is involved in the differentiation of several cell types including adipocytes. This gene is located in a region of chromosome 14 frequently showing unparental disomy, and is imprinted and expressed from the paternal allele. A single nucleotide variant in this gene is associated with child and adolescent obesity and shows polar overdominance, where heterozygotes carrying an active paternal allele express the phenotype, while mutant homozygotes are normal.