Recombinant Human IL13 (35-146) Protein, hFc Tag

Molecular Characterization: IL13 (Gly35-Asn146) hFc (Glu99-Ala330) Molecular weight: The protein has a predicted molecular mass of 38.4 kDa after removal of the signal peptide. The apparent molecular mass of IL13 (35-146) -hFc is approximately 33-53 kDa due to glycosylation.Description: Recombinant human IL13 (35-146) protein with C-terminal human Fc tagThis gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.