Recombinant Mouse CD40 Ligand Protein, hFc Tag

Molecular Characterization: hFc (Glu99-Ala330) Mouse CD40 Ligand (Gly115-Leu260) Molecular weight: The protein has a predicted molecular mass of 42.1 kDa after removal of the signal peptide. The apparent molecular mass of hFc-CD40L is approximately 40-55 kDa due to glycosylation.Description: Recombinant mouse CD40L protein with N-terminal human Fc tagCytokine that binds to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation. Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (By similarity) . Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching (PubMed: 1374165) .[UniProtKB/Swiss-Prot Function]