Recombinant Mouse GITR Ligand Protein, hFc Tag

Molecular Characterization: hFc (Glu99-Ala330) Mouse GITR Ligand (Thr47-Ser173) Molecular weight: The protein has a predicted molecular mass of 40.6 kDa after removal of the signal peptide. The apparent molecular mass of hFc-mGITRL is approximately 40-55 kDa due to glycosylation.Description: Recombinant mouse GITR Ligand protein with N-terminal human Fc tagCytokine that binds to TNFRSF18/AITR/GITR (PubMed: 14521928, PubMed: 14647196) . Regulates T-cell responses (PubMed: 14647196) . Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation (PubMed: 14608036, PubMed: 15128759) . Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B (PubMed: 14521928, PubMed: 14647196, PubMed: 18178614) . Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (By similarity) . Promotes leukocyte adhesion to endothelial cells (PubMed: 23892569) . Regulates migration of monocytes from the splenic reservoir to sites of inflammation (PubMed: 24107315) .[UniProtKB/Swiss-Prot Function]