Recombinant Mouse EGFR Protein, His Tag

Molecular Characterization: Mouse EGFR (Leu25-Ser647) 6Ã-His tagMolecular weight: The protein has a predicted molecular mass of 70.1kDa after removal of the signal peptide. The apparent molecular mass of mEGFR-His is approximately 100-130 kDa due to glycosylation.Description: Recombinant mouse EGFR protein with C-terminal6Ã-His tagReceptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed: 8404850) . Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (By similarity) . Plays a role in enhancing learning and memory performance (PubMed: 20639532) .[UniProtKB/Swiss-Prot Function]