Recombinant Human PLAUR Protein, His Tag

Molecular Characterization: PLAUR (Leu23-Arg303) 6Ã-His tagMolecular weight: The protein has a predicted molecular mass of 32.1 kDa after removal of the signal peptide. The apparent molecular mass of PLAUR-His is approximately 35-55 kDa due to glycosylation.Description: Recombinant human PLAUR protein with C-terminal6Ã-His tagThis gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined.