Recombinant Human AGR2 Protein, hFc Tag

Molecular Characterization: AGR2 (Arg21-Leu175) hFc (Glu99-Ala330) Molecular weight: The protein has a predicted molecular mass of 44.0 kDa after removal of the signal peptide. The apparent molecular mass of AGR2-hFc is approximately 35-55 kDa due to glycosylation.Description: Recombinant human AGR2 protein with C-terminal human Fc tagThis gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression.

Product Specifications

Product Name Alternative

AG-2, hAG-2, HPC8

UniProt

O95994

Host

HEK293

Target Antigen

AGR2

Components

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization.

Storage Conditions

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing) . Lyophilized proteins are shipped at ambient temperature.