Recombinant Mouse TNFRSF10B Protein, hFc Tag

Molecular Characterization: Mouse TNFRSF10B (Asn53-Lys180) hFc (Glu99-Ala330) Molecular weight: The protein has a predicted molecular mass of 40.3 kDa after removal of the signal peptide. The apparent molecular mass of mTNFRSF10B-hFc is approximately 40-55 kDa due to glycosylation.Description: Recombinant mouse TNFRSF10B protein with C-terminal human Fc tagThe protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene.

Product Specifications

Product Name Alternative

Death receptor 5, MK, CD262

UniProt

Q9QZM4

Host

HEK293

Target Antigen

TNFRSF10B

Components

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization.

Storage Conditions

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing) . Lyophilized proteins are shipped at ambient temperature.