Recombinant Mouse CB1 Protein, hFc Tag

Molecular Characterization: Mouse CB1 (Met1-Leu118) hFc (Glu99-Ala330) Molecular weight: The protein has a predicted molecular mass of 39.4 kDa after removal of the signal peptide. The apparent molecular mass of mCB1-hFc is approximately 40-55 kDa due to glycosylation.Description: Recombinant mouse CB1 protein with C-terminal human Fc tagThis gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene.