Recombinant Mouse IL17RA Protein, His Tag

Molecular Characterization: Mouse IL17RA (Ser32-Trp322) 6Ã-His tagMolecular weight: The protein has a predicted molecular mass of 34.1kDa after removal of the signal peptide. The apparent molecular mass of mIL17RA-His is approximately 55-70 kDa due to glycosylation.Description: Recombinant mouse IL17RA protein with C-terminal6Ã-His tagReceptor for IL17A (PubMed: 17911633, PubMed: 20554964, PubMed: 8777726) . Receptor for IL17F (PubMed: 17911633, PubMed: 20554964) . Binds to IL17A with higher affinity than to IL17F (PubMed: 17911633) . Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (By similarity) . Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (By similarity) . Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed: 21993848, PubMed: 21993849, PubMed: 21982598) . Activation of IL17RA leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6 (By similarity) .[UniProtKB/Swiss-Prot Function]

Product Specifications

Product Name Alternative

IL-17RA, CD217

UniProt

Q60943

Host

HEK293

Target Antigen

IL17RA

Components

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization.

Storage Conditions

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing) . Lyophilized proteins are shipped at ambient temperature.