Recombinant Mouse CD40 Protein, hFc Tag

Molecular Characterization: Mouse CD40 (Val24-Arg193) hFc (Glu99-Ala330) Molecular weight: The protein has a predicted molecular mass of 45.1 kDa after removal of the signal peptide. The apparent molecular mass of mCD40-hFc is approximately 55-70 kDa due to glycosylation.Description: Recombinant mouse CD40 protein with C-terminal human Fc tagThis gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3) . Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.