Recombinant Human ITGAX & ITGB2 Heterodimer Protein, His Tag & hFc Tag

Molecular Characterization: ITGAX (Phe20-Pro1107) 6Ã-His tag and ITGB2 (Gln23-Asn700) hFc (Glu99-Ala330) Molecular weight: The protein has a predicted molecular mass of 120.6 and 101.0 kDa after removal of the signal peptide. The apparent molecular mass of ITGAX-His and ITGB2-hFc is approximately 130-180 kDa due to glycosylation.Description: Heterodimer protein contains recombinant human ITGAX protein with C-terminal6Ã-His tag and human ITGB2 protein with C-terminal human Fc tagThis gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4) . The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene.