Recombinant Human CD63 Protein, hFc Tag

Molecular Characterization: CD63 (Ala103-Val203) hFc (Glu99-Ala330) Molecular weight: The protein has a predicted molecular mass of 37.7 kDa after removal of the signal peptide. The apparent molecular mass of CD63-hFc is approximately 35-55 kDa due to glycosylation.Description: Recombinant human CD63 protein with C-terminal human Fc tagThe protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms.

Product Specifications

Product Name Alternative

CD63 antigen?Granulophysin?LAMP-3?Limp1?Melanoma-associated antigen ME491?OMA81H?Ocular melanoma-associated antigen?Tetraspanin-30? Tspan-30

UniProt

P08962

Host

HEK293

Target Antigen

CD63

Components

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization.

Storage Conditions

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing) . Lyophilized proteins are shipped at ambient temperature.