Recombinant Human MUC18 Protein, His Tag

Molecular Characterization: MUC18 (Val24-Gly559) 6Ã-His tagMolecular weight: The protein has a predicted molecular mass of 60.6 kDa after removal of the signal peptide. The apparent molecular mass of MUC18-His is approximately 70-100 kDa due to glycosylation.Description: Recombinant human MUC18 protein with C-terminal6Ã-His tagPlays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.[UniProtKB/Swiss-Prot Function]

Product Specifications

Product Name Alternative

Cell surface glycoprotein MUC18?Cell surface glycoprotein P1H12?Melanoma cell adhesion molecule?Melanoma-associated antigen A32?Melanoma-associated antigen MUC18?S-endo 1 endothelial-associated antigen?CD146

UniProt

P43121

Host

HEK293

Target Antigen

MUC18

Components

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization.

Storage Conditions

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing) . Lyophilized proteins are shipped at ambient temperature.