Recombinant Human PRNP Protein, hFc Tag

Molecular Characterization: PRNP (Lys23-Gly229) hFc (Glu99-Ala330) Molecular weight: The protein has a predicted molecular mass of 48.8 kDa after removal of the signal peptide. The apparent molecular mass of PRNP-hFc is approximately 55-70 kDa due to glycosylation.Description: Recombinant human PRNP protein with C-terminal human Fc tagThe protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants.