Recombinant Human FLT1 Protein, His Tag

Molecular Characterization: FLT1 (Ser27-Asn756) 6Ã-His tagMolecular weight: The protein has a predicted molecular mass of 83.0 kDa after removal of the signal peptide. The apparent molecular mass of FLT1-His is approximately 100-130 kDa due to glycosylation.Description: Recombinant human FLT1 protein with C-terminal6Ã-His tagThis gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig) -like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.

Product Specifications

Product Name Alternative

VEGFR-1, Tyrosine-protein kinase FRT, FLT-1, FLT, Vascular permeability factor receptor

UniProt

P17948

Host

HEK293

Target Antigen

FLT1

Components

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization.

Storage Conditions

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing) . Lyophilized proteins are shipped at ambient temperature.