Recombinant Human Mesothelin (37-286) Protein, His Tag

Molecular Characterization: Mesothelin (37-286) (Leu37-Arg286) 6Ã-His tagMolecular weight: The protein has a predicted molecular mass of 27.6 kDa after removal of the signal peptide. The apparent molecular mass of Mesothelin (37-286) -His is approximately 25-35 kDa due to glycosylation.Description: Recombinant human Mesothelin (37-286) protein with C-terminal6Ã-His tagThis gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

Product Specifications

Product Name Alternative

CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, MPF

UniProt

Q13421

Host

HEK293

Target Antigen

Mesothelin

Components

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization.

Storage Conditions

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing) . Lyophilized proteins are shipped at ambient temperature.