Recombinant Human ITGA2 & ITGB1 Heterodimer Protein, His Tag & hFc Tag

Molecular Characterization: ITGA2 (Tyr30-Thr1132) 6Ã-His tag and ITGB1 (Gln21-Asp728) hFc (Glu99-Ala330) Molecular weight: The heterodimer protein has a predicted molecular mass of 121.8 kDa and 104.5 kDa separately after removal of the signal peptide.Description: Recombinant human ITGA2 protein with C-terminal6Ã-His tag and human ITGB1 protein with C-terminal human Fc tagIntegrin alpha 2 beta 1 is one of twelve integrin family adhesion receptors that share the beta 1 subunit. It is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Integrin ITGA2: ITGB1 acts as a receptor for Human rotavirus A and Human echoviruses 1 and 8. DGEA inhibited rotavirus binding to alpha2beta1 and infectivity. In a novel process, integrin-using viruses bind the alpha2 I domain of alpha2beta1 via DGE in VP4 and interact with alphaXbeta2 (via GPR) and alphaVbeta3 by using VP7 to facilitate cell entry and infection.

Product Specifications

Product Name Alternative

Integrin alpha 2 beta 1, ITGA2 & ITGB1

UniProt

P05556

Host

HEK293

Target Antigen

ITGA2 & ITGB1

Components

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization.

Storage Conditions

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing) . Lyophilized proteins are shipped at ambient temperature.