Recombinant Human KRAS Protein, mFc Tag

Molecular Characterization: KRAS (Thr2-Cys185) mFc (Pro99-Lys330) Molecular weight: The protein has a predicted molecular mass of 47.1 kDa after removal of the signal peptide. The apparent molecular mass of KRAS-mFc is approximately 35-55 kDa due to glycosylation.Description: Recombinant human KRAS protein with C-terminal mouse Fc tagThis gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region.

Product Specifications

Product Name Alternative

C-K-RAS; c-Ki-ras2; CFC2; K-Ras; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KI-RAS; KRAS1; KRAS2; NS; NS3; RALD; RASK2

UniProt

P01116

Host

HEK293

Target Antigen

KRAS

Components

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization.

Storage Conditions

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing) . Lyophilized proteins are shipped at ambient temperature.