Recombinant Human GUCY2C Protein, His Tag

Molecular Characterization: GUCY2C (Ser24-Gln430) 6Ã-His tagMolecular weight: The protein has a predicted molecular mass of 46.8 kDa after removal of the signal peptide. The apparent molecular mass of GUCY2C-His is approximately 55-130 kDa due to glycosylation.Description: Recombinant human GUCY2C protein with C-terminal6Ã-His tagThis gene encodes a transmembrane protein that functions as a receptor for endogenous peptides guanylin and uroguanylin, and the heat-stable E. coli enterotoxin. The encoded protein activates the cystic fibrosis transmembrane conductance regulator. Mutations in this gene are associated with familial diarrhea (autosomal dominant) and meconium ileus (autosomal recessive) .

Product Specifications

Product Name Alternative

DIAR6, GC-C, GUC2C, MECIL, MUCIL, STAR

UniProt

P25092

Host

HEK293

Target Antigen

GUCY2C

Components

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization.

Storage Conditions

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing) . Lyophilized proteins are shipped at ambient temperature.