Recombinant Human NTRK1 Protein, hFc Tag

Molecular Characterization: NTRK1 (Ala33-Phe410) hFc (Glu99-Ala330) Molecular weight: The protein has a predicted molecular mass of 67.4 kDa after removal of the signal peptide.The apparent molecular mass of NTRK1-hFc is approximately 70-130 kDa due to glycosylation.Description: Recombinant Human NTRK1 Protein with C-terminal human Fc tagThis gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.

Product Specifications

Product Name Alternative

MTC, p140-TrkA, TRK, Trk-A, TRK1, TRKA

UniProt

P04629

Host

HEK293

Target Antigen

NTRK1

Components

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization.

Storage Conditions

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing) . Lyophilized proteins are shipped at ambient temperature.