Recombinant Human PSMA Protein, mFc Tag

Molecular Characterization: mFc (Pro99-Lys330) PSMA (Lys44-Ala750) Molecular weight: The protein has a predicted molecular mass of 105.8 kDa after removal of the signal peptide.The apparent molecular mass of mFc-PSMA is approximately 130 kDa due to glycosylation.Description: Recombinant human PSMA protein with N-terminal mouse Fc tagThis gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms.