Recombinant Human P2RX7 Protein, hFc Tag

Molecular Characterization: hFc (Glu99-Ala330) P2RX7 (Ser47-Val334) Molecular weight: The protein has a predicted molecular mass of 59.2 kDa after removal of the signal peptide. The apparent molecular mass of hFc-P2RX7 is approximately 55-70 kDa due to glycosylation.Description: Recombinant human P2RX7 protein with N-terminal human Fc tagThe product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria.