Recombinant Mouse BTLA Protein, mFc Tag

Molecular Characterization: Mouse BTLA (Glu30-Pro176) mFc (Pro99-Lys330) Molecular weight: The protein has a predicted molecular mass of 42.7 kDa after removal of the signal peptide.The apparent molecular mass of Mouse-BTLA-mFc is approximately 55-70 kDa due to glycosylation.Description: Recombinant mouse BTLA protein with C-terminal mFc tagInhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed: 12796776, PubMed: 14652006) . May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14 (PubMed: 19915044) . In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed: 19915044) .