Recombinant Human TLR3 Protein, hFc Tag

Molecular Characterization: TLR3 (Glu28-Pro80) hFc (Glu99-Ala330) Molecular weight: The protein has a predicted molecular mass of 103.5 kDa after removal of the signal peptide. The apparent molecular mass of TLR3-hFc is approximately 130-180 kDa due to glycosylation.Description: Recombinant human TLR3 protein with C-terminal human Fc tagThe protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.