Human APP Protein, His Tag

Molecular Weight: Human APP protein has a predicted molecular mass of 74.6 kDa after removal of the signal peptide.The apparent molecular mass of APP-His is approximately 100-130 kDa due to glycosylation. Molecular Characterization: APP (Leu18-Val669) 6XHis Tag Human APP gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy) . Multiple transcript variants encoding several different isoforms have been found for this gene.