Human CD93 Protein, hFc Tag

The protein has a predicted molecular mass of 84.4 kDa after removal of the signal peptide. The apparent molecular mass of CD93-hFc is approximately 130-250 kDa due to glycosylation. The protein encoded by this gene is a cell-surface glycoprotein and type I membrane protein that was originally identified as a myeloid cell-specific marker. The encoded protein was once thought to be a receptor for C1q, but now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells. The intracellular cytoplasmic tail of this protein has been found to interact with moesin, a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton.