Human SLC4A7 Protein, His Tag

The protein has a predicted molecular mass of 68.6 kDa after removal of the signal peptide. The apparent molecular mass of SLC4A7-His is approximately 100-130 kDa due to glycosylation. This locus encodes a sodium bicarbonate cotransporter. The encoded transmembrane protein appears to transport sodium and bicarbonate ions in a 1:1 ratio, and is thus considered an electroneutral cotransporter. The encoded protein likely plays a critical role in regulation of intracellular pH involved in visual and auditory sensory transmission. Alternatively spliced transcript variants encoding distinct isoforms have been described.