Human GPR77 (1-38) Protein, hFc Tag

The protein has a predicted molecular mass of 30.2 kDa after removal of the signal peptide. The apparent molecular mass of GPR77 (1-38) -hFc is approximately 35-55 kDa due to glycosylation. This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants.